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Objectives - Patients frequently ask questions about the lifetime prognosis of Crohn’ s disease. The aim of this study was to describe the outcomes of Cro hn’ s disease more than 20 years after diagnosis. Methods - Data from all pat ients with Crohn’ s disease whose diagnosis had been performed before 1st Janua ry 1978 were analyzed. All referred patients filled in a medical and health- re lated quality- of- life questionnaire. Results - Among 273 patients with Cro hn’ s disease diagnosed more than 20 years ago, 141 (52% ) patients answered o ur questionnaire, 45 (16% ) patients were alive but did not wish to answer our questionnaire, 51 (19% ) could not be traced and 36 (13% ) died before July 19 98. At the end of follow- up, 25.7 (20.0- 59.3) years after diagnosis, 24% h ad a relapse in the previous 12 months, and 48% and 28% had quiescent diseas e with and without treatment, respectively. These ratios were not different from those observed three years after Crohn’ s disease diagnosis. Sixteen patients died within 20 years after CD diagnosis, including 11 from CD- related causes. The risk of death estimated by Kaplan- Meier life- tables analysis was non- s ignificantly higher if death was related to CD. An ileal or colic adenocarcinoma was noted in 6 (3.4% ) patients. Conclusions - Crohn’ s disease activity do es not burn out with time, and roughly one- quarter of the patients had active disease 20 years after diagnosis.
Objectives - Patients frequently ask questions about the lifetime prognosis of Crohn ’s disease. The aim of this study was to describe the outcomes of Cro hn’ s disease more than 20 years after diagnosis. Methods - Data from all pat ients with Crohn ’s all whose patients filled in a medical and health- re lated quality- of-life questionnaire. Results - Among 273 patients with Crohn’s disease diagnosed more than 20 years ago , 141 (52%) patients answered o ur questionnaire, 45 (16%) patients were alive but did not not wish to answer our questionnaire, 51 (19%) could not be traced and 36 (13%) died before July 19 98. At the end of follow-up, 25.7 (20.0- 59.3) years after diagnosis, 24% h ad a relapse in the previous 12 months, and 48% and 28% had quiescent diseas e with and without treatment, respectively. These ratios were not different from those observed three years after Crohn’s disease diagnosi Sixteen patients died within 20 years after CD diagnosis, including 11 from CD-related causes. The risk of death estimated by Kaplan-Meier life-tables analysis was non-ignificantly higher if death was related to CD. An ileal or colic Conclusions - Crohn’s disease activity do es not burn out with time, and roughly one-quarter of the patients had active disease 20 years after diagnosis.