论文部分内容阅读
目的探讨脑膜瘤(IM)和脊膜瘤(SM)中IL-1α和IL-6的表达及其临床意义。方法采用免疫组化方法检测IM(IM组,118例)和SM(SM组,44例)中的IL-1α和IL-6表达水平,分析其组间及其病理分型之间的表达差异。结果 IM和SM病理分型的各亚型之间,IL-1α和IL-6的表达均有统计学差异(P<0.05)。非良性IM组的IL-1α阳性率为78.9%,高于良性IM组的33.3%(P<0.05);非良性IM组的IL-6阳性率为31.6%,与良性IM组的17.2%相仿(P>0.05)。结论IM与SM组织及其病理分型的IL-1α和IL-6表达水平有显著差异,可为临床诊断提供一定参考。
Objective To investigate the expression of IL-1α and IL-6 in meningioma (IM) and meningioma (SM) and its clinical significance. Methods Immunohistochemical method was used to detect the expression of IL-1α and IL-6 in IM (IM group, 118 cases) and SM (SM group, 44 cases), and to analyze the expression difference between groups and their pathological types . Results There was a significant difference in the expression of IL-1α and IL-6 between different subtypes of IM and SM (P <0.05). The positive rate of IL-1α in non-benign IM group was 78.9%, which was higher than that in benign IM group (P <0.05). The positive rate of IL-6 in non-benign IM group was 31.6%, which was similar to 17.2% in benign IM group (P> 0.05). Conclusion The expression levels of IL-1α and IL-6 in IM and SM tissues and their pathological types are significantly different, which may provide some reference for clinical diagnosis.