论文部分内容阅读
目的：评价蛇床子总香豆素（ＴＣＣＭ）对糖皮质激素（ＧＣ）致大鼠骨质疏松的骨密度（ＢＤ）和生物力学性能的影响．方法：２４只３月龄♂ＳＤ大鼠，体重３４０±５ｇ，随机分为对照（Ａ）组、ＧＣ（Ｂ）组和预防（Ｃ）组，Ｂ和Ｃ组均喂醋酸泼尼松４５ｍｇ·ｋｇ－１，每周２次；Ｃ组还喂ＴＣＣＭ２０ｍｇ·ｋｇ－１ｉｇ，每周６次．持续９０ｄ．结果：Ｂ组（与Ａ组比较）大鼠股骨近、中和远段ＢＤ分别减少了１２％、１４％和１２％；Ｃ组（与Ｂ组比较）ＢＤ则分别增加了２６％、３４％和３１％．Ｃ组（与Ｂ组比较）股骨的扭转强度和能量分别增加了１５％和３２％．结论：ＴＣＣＭ除能防止ＧＣ所致骨量丢失外，还能增加其抗扭转强度．
Objective: To evaluate the effect of total coumarin (TCCM) from Cnidium monnieri on bone mineral density (BD) and biomechanical properties of rat osteoporosis induced by glucocorticoid (GC). METHODS: Twenty-four Sprague-Dawley rats aged 3 months and a body weight of 340±5 g were randomly divided into control group (A), GC (B) group and prevention (C) group. Both groups B and C were treated with prednisone acetate. 5mg · kg-1, 2 times a week; C group also fed TCCM 20mg · kg-1ig, 6 times per week. Last 90d. RESULTS: B group (compared with group A) had a 12%, 14%, and 12% decrease in BD in the proximal, middle and distal femurs, respectively; in group C (compared with group B), BD increased by 26% and 34%, respectively. And 31%. The torsional strength and energy of the femur in group C (compared with group B) increased by 15% and 32%, respectively. Conclusion: TCCM can increase its torsional strength in addition to preventing GC-induced bone loss.