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收集17名正常人,20名单纯肥胖患者,42名2型糖尿病患者的临床资料,以彩色血管多普勒超声探测受试者的双下肢股动脉、动脉、胫前动脉、胫后动脉及足背动脉,并测量内中膜最厚处厚度及斑块数目、管腔狭窄程度。结果①在2型糖尿病组动脉粥样硬化斑的阳性率显著高于正常组及单纯肥胖组(P值分别<0.05及<0.01),且内中膜厚度显著大于后二者(P值分别<0.05及<0.01)。2型糖尿病组较正常对照组及单纯肥胖组动脉损伤发生率高、程度重(P值分别<0.05及<0.01)。②2型糖尿病患者中,下肢动脉硬化与体重指数、腰围呈显著正相关(P<0.01)。结论在本资料的2型糖尿病患者中,90%已有动脉粥样硬化,中心性肥胖对2型糖尿病患者动脉硬化有显著影响。
The clinical data of 17 normal subjects, 20 simple obesity patients and 42 type 2 diabetic patients were collected. The femoral artery, popliteal artery, anterior tibial artery and posterior tibial artery of both lower extremities were detected by color Doppler sonography. The dorsalis pedis artery was measured and the thickness and the number of plaques at the thickest endometrium and the degree of lumen stenosis were measured. Results ① The positive rate of atherosclerotic plaque in type 2 diabetes mellitus group was significantly higher than that in normal group and simple obesity group (P <0.05 and <0.01, respectively), and the intima thickness was significantly greater than the latter two groups (P < 0.05 and <0.01). The incidence of arterial injury in type 2 diabetes group was higher than that in control group and simple obesity group (P <0.05 and <0.01, respectively). In type 2 diabetic patients, lower extremity arteriosclerosis was positively correlated with body mass index and waist circumference (P <0.01). Conclusions 90% of patients with type 2 diabetes mellitus have atherosclerosis and central obesity has a significant effect on atherosclerosis in patients with type 2 diabetes.