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对５６１例老年及老年前期肾功能检查的研究结果表明，老年人中有８７．２％存在不同程度的肾小球功能受损，而ＢＵＮ和Ｓｃｒ并不增高，血、尿β２－ＭＧ却明显增高。相关分析表明：老年人血β２－ＭＧ浓度与Ｃｃｒ呈非常显著负相关，尿β２－ＭＧ与ＵＯｓｍ呈非常显著负相关，血、尿β２－ＭＧ均与年龄呈非常显著正相关，认为血β２－ＭＧ大于２．０ｍｇ／Ｌ可判断肾小球功能已受损，并指出老年人ＧＦＲ减退从年龄上要早于肾小管在吸收功能的减退，但在吸收功能的减退从速度上要快于ＧＦＲ减退，肾小管功能的减退前先是浓缩稀释功能的减退；糖尿病和高血压病β２－ＭＧ升高明显，说明老年人合并糖尿病或高血压病者肾功能容易受损。
The results of 561 elderly and elderly patients with renal function tests showed that 87.2% of the elderly had different degrees of glomerular dysfunction, while BUN and Scr did not increase, blood and urine β2-MG was significantly Increase. Correlation analysis showed that there was a very significant negative correlation between blood concentration of β2-MG and Ccr in the elderly, urinary β2-MG and UOsm showed a very significant negative correlation, blood and urine β2-MG were significantly and positively correlated with age, that blood β2- MG is greater than 2.0mg / L glomerular function can be judged to have been impaired, and pointed out that the elderly GFR decline from earlier than the renal tubule in the absorption function of the decline, but the decline in absorption speed faster than the GFR Diminished before the decline of renal tubular function before the decline of concentration and dilution; diabetes and hypertension β2-MG increased significantly, indicating that older people with diabetes or hypertensive renal function easily damaged.