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目的探讨肿瘤患者大量输血后临床检验指标的变化。方法 142例肿瘤患者,均给予大量输血,比较输血前后临床检验指标。结果输血前,血小板(PLT)计数为(189.22±96.42)×10~9/L,凝血酶原时间(PT)为(15.07±2.67)s,国际标准化比值(INR)为(1.44±0.46),活化部分凝血酶时间(APTT)为(37.61±6.13)s,纤维蛋白原(FIB)为(2.64±1.13)g/L,凝血酶时间(TT)为(16.11±2.38)s;输血后,PLT计数为(115.01±53.87)×10~9/L,PT为(16.67±5.21)s,INR为(1.26±0.28),APTT为(39.54±7.41)s,FIB为(2.21±0.88)g/L,TT为(18.33±4.57)s。输血后,患者PLT计数、INR、FIB均低于输血前,PT、APTT、TT均长于输血前,差异具有统计学意义(P<0.05)。结论大量输血对大失血的肿瘤患者是非常重要的治疗手段,然而临床医生应该高度警惕大量输血以后的各种并发症,及时对患者的PLT输血、功能以及凝血功能给予检测,进而能够有效防治并发症的发生。当大失血的肿瘤患者出血已经停止,可以考虑限制性输血方式,进而降低输血不良影响。
Objective To investigate the changes of clinical test indexes after massive blood transfusion in cancer patients. Methods A total of 142 patients with cancer were given large amounts of blood transfusions. The clinical indexes before and after transfusion were compared. Results Before transfusion, the platelet count (PLT) was (189.22 ± 96.42) × 10 ~ 9 / L, the prothrombin time (PT) was 15.07 ± 2.67 and the international normalized ratio was 1.44 ± 0.46. The activated partial thromboplastin time (APTT) was (37.61 ± 6.13) s, the fibrinogen (FIB) was (2.64 ± 1.13) g / L and the thrombin time (TT) The counts were (115.01 ± 53.87) × 10-9 / L, PT was (16.67 ± 5.21) s, INR was (1.26 ± 0.28), APTT was (39.54 ± 7.41) s, FIB was (2.21 ± 0.88) g / L , TT was (18.33 ± 4.57) s. After transfusion, PLT count, INR, FIB were lower than before transfusion, PT, APTT, TT were longer than before transfusion, the difference was statistically significant (P <0.05). Conclusions Massive blood transfusion is a very important treatment for patients with large blood loss. However, clinicians should be highly vigilant for various complications after massive blood transfusion and timely detect the PLT blood transfusion, function and coagulation function of the patients so as to effectively prevent and treat the complications Occurrence of the disease. When bleeding patients with large blood loss has stopped bleeding, you can consider restrictive transfusion, and thus reduce the adverse effects of transfusion.