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测定了20例难治性充血性心力衰竭患者应用氨利酮冶疔前后淋巴细胞内环核苷酸和Ca~(2+)含量,同时用热稀释法测定其心指数。氨利酮治疗后淋巴细胞内cAMP和Ca~(2+)含量较治疗前明显升高且与心指数增加的时程相似,治疗前后cAMP和Ca~(2+)与心指数之间均呈显著正相关。提示氨利酮可能通过增加心肌细胞内cAMP和Ca~(2+)浓度发挥正性肌力作用。淋巴细胞cAMP和Ca~(2+)的测定对估计心衰严重程度及判断药物疗效可能有一定意义。
The content of intracellular nucleotides and Ca ~ (2+) in lymphocytes in patients with refractory congestive heart failure before and after treatment with aminomethyl ketone was determined. The cardiac index was also determined by thermal dilution method. After treatment with aminomethyl ketone, the levels of cAMP and Ca 2+ in lymphocytes were significantly higher than those before treatment and similar to those of cardiac index. The levels of cAMP, Ca 2+ and cardiac index before and after treatment Significantly positive correlation. It is suggested that aminimone may exert positive inotropic effect by increasing intracellular cAMP and Ca ~ (2+) concentration. The determination of cAMP and Ca ~ (2 +) in lymphocytes may have some significance for estimating the severity of heart failure and judging the efficacy of drugs.