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组织相容性、机体免疫状态以及糖皮质激素、硫唑嘌呤、环孢菌素(CsA)、抗淋巴细胞球蛋白等免疫抑制剂的应用是逐步改善移埴肾存活率的重要因素。几乎所有的免疫抑制方案都以 CsA 为基础。抗淋巴细胞球蛋白诱导免疫后,可延迟使用 CsA,使正在从保存过程损伤恢复的移植肾免受肾毒性的再次损伤。从免疫抑制方案中撤去 CsA,可降低尸肾移植存活率。排斥反应通常用大剂量激素冲击治疗。FK-506是迄今很有前途的一种新免疫抑制药物。
Tissue compatibility, immune status and the application of immunosuppressive agents such as glucocorticoids, azathioprine, cyclosporine (CsA) and anti-lymphocyte globulin are important factors in gradually improving the survival rate of transplanted kidneys. Almost all immunosuppressive regimens are based on CsA. After induction of immunity with anti-lymphocyte globulin, CsA can be delayed, renaturation of kidney grafts that are being damaged from the preservation process from re-injury of nephrotoxicity. CsA withdrawal from immunosuppressive regimen can reduce the survival rate of cadaveric kidney transplantation. Rejection reaction is usually treated with high-dose hormone shock. FK-506 is by far a promising new immunosuppressive drug.