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目的:探讨甲状腺髓样癌(MTC)的临床细胞病理学特点及鉴别诊断,提高对甲状腺髓样癌的认识和诊断水平。方法:分析2例经病理组织学证实的甲状腺髓样癌的临床表现及细胞病理学特征,免疫表型。结果:例1男,56岁,右侧甲状腺结节,随吞咽活动无其他不适,镜下为梭形细胞,呈束状排列,细胞间见红染的淀粉样物,细胞病理学报告疑MTC,组织病理学诊断为MTC(梭形细胞型),免疫表型CaL(+),TG(-),NES(+);例2女,35岁,右侧甲状腺结节,质硬,随吞咽活动,镜下为圆形,椭圆形细胞,细胞质少,细胞病理学诊断考虑MTC,组织病理学诊断为MTC(小细胞型),免疫表型:CaL(-),TG(-),NES(+)。结论:充分掌握MTC的临床细胞病理学特征,结合患者的临床资料,进行总结及复习,能有效地提高诊断水平。
Objective: To investigate the clinical cytopathological features and differential diagnosis of medullary thyroid carcinoma (MTC) and to improve the understanding and diagnosis of medullary thyroid carcinoma. Methods: The clinical manifestations, cytopathological features and immunophenotype of 2 medullary thyroid carcinoma confirmed by histopathology were analyzed. Results: A male, 56 years old, right thyroid nodules, with no other discomfort with swallowing activity, microscopic spindle cells, were arranged in bundles, the cells see the red stained starch, cytopathology reported suspected MTC Histopathological diagnosis of MTC (spindle cell type), immunophenotype CaL (+), TG (-), NES (+); 2 female, 35 years old, right thyroid nodules, hard, with swallowing MLC (small cell type), immunophenotype: CaL (-), TG (-), NES (P <0.05) +). Conclusion: To fully grasp the clinical cytopathological features of MTC, combined with the clinical data of patients, to summarize and review, can effectively improve the diagnostic level.