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目的探讨不同加力方式对尖牙远中移动速度及其龈沟液中基质金属蛋白酶-1(matrix metalloproteinase-1,MMP-1)及金属基质蛋白酶抑制剂-1(tissue inhibitor of metalloproteinases-1,TIMP-1)表达的影响。方法选取根据需要拔除了4个第一双尖的24名女性患者随机分为2组,A组:橡皮链组;B组:镍钛拉簧组。每组均施加150g的初始拉力远中移动上下颌尖牙。分别在加力前,加力后1周、2周、4周、6周分别收集右侧上下颌尖牙处的龈沟液、采集上下颌模型。应用ELISA方法测定所取龈沟液中的MMP-1和TIMP-1的浓度,用游标卡尺分别测量上下颌尖牙的移动距离。对所测得的数据进行统计学分析。结果 1AB两组无论上颌还是下颌,均在加力后第1周移动距离最大,差别具有统计学意义。在第2周开始逐渐减慢,到第5、6周时上下颌尖牙几乎停止移动。6周总的移动距离,A组小于B组,差异具有统计学意义(P<0.05)。2A组和B组无论上下颌MMP-1及TIMP-1在加力后浓度变化在加力后1周时,AB两组的上下颌尖牙龈沟液中MMP-1及TIMP-1浓度均开始上升,且达到最高峰,随后开始下降.但B组与A组相比,浓度均变化更加均匀且稳定(P<0.05)。结论 1在相同初始力量的情况下,镍钛拉簧较橡皮链远中移动尖牙移动幅度较大,且产生的生物学效应较持久。2MMP-1及TIMP-1早期即参加了正畸牙周组织改建,且其相互平衡对牙周组织改建以及牙齿的快速移动中起到重要作用。
Objective To investigate the effects of different ways of applying force on distal movement of canines and the relationship between matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP) -1) expression. Methods According to the need to remove the four first double-tip of 24 female patients were randomly divided into two groups, A group: rubber chain group; B group: NiTiLa group. Each group were applied 150g of the initial pull distal jaw teeth move. The gingival crevicular fluid on the right maxillary and mandibular canines were collected before force, 1 week, 2 weeks, 4 weeks and 6 weeks after application of force. The maxillary and mandibular models were collected. The concentration of MMP-1 and TIMP-1 in gingival crevicular fluid was measured by ELISA, and the movement distance of maxillary and mandibular canine were measured by vernier caliper. The measured data were statistically analyzed. Results Both groups 1AB had maximal movement or mandibular movement at the first week after application of force, the difference was statistically significant. Gradually slowed down from the second week to the fifth and the fifth week, the maxillary canines almost stopped moving. The total moving distance of 6 weeks, group A less than group B, the difference was statistically significant (P <0.05). In group 2A and group B, the concentrations of MMP-1 and TIMP-1 in upper and lower jaw gingival crevicular fluid in both AB groups began to change (P <0.05), but the peak began to decrease and then began to decrease, but the concentration in group B was more uniform and stable than that in group A (P <0.05). Conclusion 1 Under the same initial force, the movement of NiTi tension spring is larger than that of the movable rubber can and the biological effect is longer lasting. In the early stage, 2MMP-1 and TIMP-1 participated in orthodontic periodontal remodeling, and their mutual balance plays an important role in periodontal remodeling and rapid tooth movement.