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用Wistar大鼠130只及昆明小鼠100只分为4组。1,2,3组动物均灌喂6.4g/L亚硝酸钠溶液和10g/L甲基苄胺溶液。第2,3组动物在灌喂上述液体的同时,分别再灌喂1500g/L山楂提取液,1.35g/L维生素C溶液。第4组动物灌喂蒸馏水作为对照。大鼠在灌喂40次,小鼠为16次后处死。实验表明:灌喂亚硝酸钠溶液和甲基苄胺溶液的小鼠及大鼠,其食管及前胃上皮均有不同程度的增生性病变,其中5只大鼠诱发了前胃乳头状瘤。若灌喂亚硝酸钠溶液和甲基苄胺溶液的小鼠及大鼠,同时再灌喂山楂提取液时,食管或前胃上皮均无明显形态学变化。提示山楂提取液对体内合成甲基苄基亚硝胺诱癌有显著的阻断作用。
130 Wistar rats and 100 Kunming mice were divided into 4 groups. 1,2,3 groups of animals were fed with 6.4 g/L sodium nitrite solution and 10 g/L methylbenzylamine solution. The second and third groups of animals were fed with 1500 g/L hawthorn extract and 1.35 g/L vitamin C solution. The fourth group of animals was fed with distilled water as a control. Rats were fed 40 times and mice 16 times after sacrifice. Experiments showed that mice and rats fed with sodium nitrite solution and methylbenzylamine solution had proliferative lesions of different degrees in the esophagus and pre-gastric epithelium, and 5 of them induced pre-vaginal papilloma. When mice and rats fed with sodium nitrite solution and methylbenzylamine solution were fed with the hawthorn extract at the same time, there was no obvious morphological change in the esophagus or the epigastric epithelium. It is suggested that hawthorn extract has a significant blocking effect on in vivo synthesis of methylbenzylnitrosamines.