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原发性尿崩症一般采用各种剂型的垂体后叶素进行替代疗法。但某些病人用鼻部吸入法可引起鼻粘膜萎缩,有些人因过敏反应而发生支气管痉挛,其他用肌注途径给药者则需每天打针,而且常常因药物没有充分混和导致控制不佳。1959年首次报导口服氯噻嗪治疗尿崩症,以后报导氯磺丙脲有类似效果,但有低血糖、胃肠道障碍和过敏反应等许多副作用。1967年首次报导安妥明(Clofibrate)对原发性尿崩症的抗利尿作用,以后为其他作者所证实。 1973年Yusoof报告1例35岁原发性尿崩症患者,从小有烦渴、多尿的病史,对肌注垂体后叶素反
Primary diabetes insipidus is generally used in various forms of pituitrin replacement therapy. However, some patients with nasal inhalation can cause nasal mucosa atrophy, some people because of allergic reactions and bronchospasm, the other intramuscular injection of the need for daily injection, and often because of the drug is not fully mixed resulting in poor control. The first oral chlorothiazide reported in 1959 in the treatment of diabetes insipidus, reported after chlorpromazine have similar effects, but there are many side effects such as hypoglycemia, gastrointestinal disorders and allergic reactions. The antidiuretic effect of Clofibrate on primary diabetes insipidus was first reported in 1967 and later confirmed by other authors. Yusoof 1973 report of a 35-year-old patients with primary diabetes insipidus, polydipsia history of polyuria, intramuscular injection of vasopressin anti