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1939年以米,关于生长激素分泌过多在糖尿病病因中的作用一直存在争论。本文报导在新发病的糖尿病患者,最初的胰岛素治疗对矫正不正常的生长激素的可能效果及其所需时间。作者对5例新发病的必需用胰岛素治疗的男性重型糖尿病患者,于胰岛素治疗前后进行生长激素测定,并与正常的7例作了比较。患者年龄16～27岁,在诊断时体重均低于正常标准,并有典型症状,均无明显酮疵、酸中毒。诊断后即开始研究,测定24小时内血浆生长激素浓度。其后,全部患者用普通胰岛素和中效胰岛素(NPH),每天于早餐及晚餐前2次注射。治疗1月后,所有病例再次入院,重复生长激素测定。其中2例因生长激素分泌仍明显异常,于胰岛
In 1939, there has been controversy over the role of excess growth hormone in the etiology of diabetes. This article reports on the possible effects of initial insulin therapy on correcting abnormal growth hormone and its time in newly diagnosed diabetic patients. The authors tested growth hormone in five newly diagnosed male patients with essential diabetes who were insulin-treated before and after insulin therapy and compared them to the normal seven. Patients aged 16 to 27 years of age, weight at diagnosis are lower than the normal standard, and typical symptoms, no obvious ketone defects, acidosis. After the diagnosis began to study the determination of plasma growth hormone concentrations within 24 hours. Thereafter, all patients were treated with normal and intermediate-effect insulin (NPH) twice a day before breakfast and dinner. After 1 month of treatment, all cases were re-admitted to the hospital and the determination of growth hormone was repeated. In 2 cases, the secretion of growth hormone was still significantly abnormal in the islets