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在组织和血浆中在激肽释放酶(KK)作用下分别产生赖氨酰缓激肽(LBK)和缓激肽(BK),二者均可增加肾血流量和水、盐排出。肾内和尿中的KK一致,但和血浆KK有显著差异。肾内KK是种胞外酶,主要位于远曲小管上皮细胞的腔面,并可释放入小管液中,少部分KK进入肾血流或间质。血浆中有高、低分子量型的二种激肽原(Kn),低分子量型Kn漏过肾小球,不被近曲小管重吸收,在远曲小管中由尿中或细胞顶端的作用而形成激肽(K)。肾内含量最高的激肽酶(Ka)是KaⅡ,它水解C端的苯丙氨酸和精氨酸
Lysyl bradykinin (LBK) and bradykinin (BK) are produced in tissues and plasma under the action of kallikrein (KK), both of which increase renal blood flow and water and salt excretion. KK in the kidney and urine are consistent, but there is a significant difference from plasma KK. Renal KK is an extracellular enzyme, mainly located in the distal surface of the tubule epithelial cells, and can be released into the small tube of fluid, a small part of KK into the renal blood flow or interstitial. Plasma has high and low molecular weight of two kinds of kininogen (Kn), low-molecular-weight Kn through the glomerular, not proximal tubule reabsorption in the distal convoluted tubules by urine or cell top and The formation of kinin (K). Kinin (Ka), the most abundant in the kidney, is KaII, which hydrolyzes C-terminal phenylalanine and arginine