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比较乙型脑炎活疫苗与灭活疫苗在小白鼠的免疫原性。结果表明以腹腔攻击法测定,活疫苗免疫1钟后7天和14天的保护率无下降,而灭活疫苗免疫2针后14天的保护率较7天下降30%~50%。以脑内攻击法测定,活疫苗免疫1外或2针的保护率为70%~90%。而灭活疫苗免疫2针的保护率仅为10%~33%。活疫苗免疫后动物中和抗体水平虽然很低(1:5),但仍有很强的保护力。提示活疫苗免疫的保护力除体液免疫外可能还存在细胞免疫。
To compare the immunogenicity of Japanese encephalitis live vaccine and inactivated vaccine in mice. The results showed that the protection rate of 7 days and 14 days after inoculation of live vaccine did not decrease with the method of intraperitoneal attack, while the protection rate of 14 days after inactivated vaccine dropped from 30% to 50% after 7 days and 14 days. Measured by intracerebral challenge, the protection rate of live vaccine against external 1 or 2 needles was 70% -90%. Inactivated vaccination 2 needle protection rate of only 10% to 33%. Animal vaccination after neutralization of antibody levels in animals although very low (1: 5), but still strong protection. Tip live vaccine immunity in addition to humoral immunity may exist in addition to cellular immunity.