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目的 探讨治疗抗磷脂综合征妇女反复妊娠流产和死胎的有效方法。方法 抗磷脂抗体阳性者采用小剂量阿斯匹林75mg 每日一次口服2 周,9 例抗体持续阳性者改用肝素6 250IU 每12 小时1 次皮下注射及泼尼松5mg每日1 次口服至抗体阴性停用。结果 9 例患者中有8 例胎儿存活,平均孕周为36 周,无与药物有关的严重并发症。结论 肝素的使用可增加围产期胎儿存活率,结果证实上述三种药物的小剂量合理应用是安全有效的。
Objective To investigate the effective treatment of abortion and stillbirth after repeated pregnancy in women with antiphospholipid syndrome. Methods Antiphospholipid antibody-positive patients with low-dose aspirin 75mg orally once daily for 2 weeks, 9 patients with persistent positive conversion to heparin 6 250IU once every 12 hours subcutaneous injection and prednisone 5mg orally daily Antibody negative disabled. Results Of the 9 patients, 8 fetuses survived with an average gestational age of 36 weeks, with no serious drug-related complications. Conclusion The use of heparin can increase the fetal survival rate during perinatal period. The results confirm that safe and effective administration of small doses of the above three drugs is reasonable.