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目的观察卡前列甲酯栓（卡孕栓）对产后出血发生的影响及其副作用。方法将正常足月妊娠阴道分娩者８０例随机分成３组，其中２组为卡孕栓实验组，以不同给药途径分为阴道用药组（２５例）与舌下含服组（２５例），对照组（３０例）则常规静脉推注麦角新碱。结果３组产妇的第３产程平均时间分别是７．６４、５．５２和６．４４ｍｉｎ，无明显统计学差异（Ｐ＞０．０５）；产后２ｈ内的平均出血量，对照组（２６０．８３ｍｌ）与卡孕栓阴道给药组（１９０．２８ｍｌ）及舌下含服组（１９９．８０ｍｌ）相比均有显著差异（Ｐ＜０．００１）；两卡孕栓组间则未见差异。两实验组产妇均未发生明显副反应。结论卡孕栓预防产后出血的效果优于麦角新碱，其阴道用药及舌下含服都是有效给药途径。
Objective To observe the effect and its side effects of carbamazepin suppository on the postpartum hemorrhage. Methods 80 cases of normal full-term pregnancy vaginal delivery were randomly divided into three groups, of which two groups of carboplatin suppository experimental group were divided into vaginal administration group (25 cases) and sublingual group (25 cases) , While the control group (30 patients) received routine intravenous administration of ergonovine. Results The average time of third stage of labor was 7.64,5.52 and 6.44min in the three groups, with no significant difference (P> 0.05). The average amount of bleeding within 2h after delivery was significantly lower in the control group (260%). 83ml) had significant difference (P <0.001) compared with the vaginal administration group (190.28ml) and the sublingual group (199.80ml); there was no difference between the two control groups . No significant side effects occurred in the two experimental groups. Conclusions Carprost suppository is superior to ergometrine in preventing postpartum hemorrhage. Both vaginal and sublingual administration are effective routes of administration.