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目的:分析新生儿ICU侵袭性真菌感染高危因素及其早期诊断方法。方法:选取2013年5月—2015年5月期间收治的侵袭性真菌感染患儿55例,采用回顾性分析方法分析侵袭性真菌感染的高危因素以其预后。结果:患儿经1,3-β-D-葡聚糖的检测,结果示阳性例数为55例,阳性率为30.56%(55/180);随后通过血培养检测,结果示阳性例数为10例,阳性率为18.18%(10/55);念珠菌示阳性例数为6例(其中2例光滑念珠菌,3例热带念珠菌和1例克柔念珠菌感染),白假丝酵母菌示阳性例数为3例,毛霉菌示阳性例数为1例。结论:侵袭性真菌感染常见于早产儿,主要病原菌为念珠菌;在临床治疗中有助于早期诊断,科学合理地使用抗生素治疗。
Objective: To analyze the risk factors of invasive fungal infection in neonates with ICU and its early diagnosis. Methods: Fifty-five children with invasive fungal infection were selected from May 2013 to May 2015. Retrospective analysis was used to analyze the risk factors of invasive fungal infection with its prognosis. Results: In children with the detection of 1,3-β-D-glucan, the results showed that the positive number of 55 cases, the positive rate was 30.56% (55/180); followed by blood culture test, the results showed positive cases 10 cases, the positive rate was 18.18% (10/55); Candida positive cases were 6 cases (2 cases of Candida glabrata, 3 cases of Candida tropicalis and Candida krusei infection), white false silk Yeasts showed positive cases in 3 cases, Mucormycosis cases showed positive cases in 1 case. Conclusions: Invasive fungal infection is common in preterm infants and Candida albicans is the main pathogen. Early diagnosis is helpful in clinical treatment and antibiotics are used scientifically and rationally.