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具有ＨＬＡ ＤＲ7等位基因的个体比不具该等位基因的个体更易患硬皮病。细胞色素Ｐ4 5 0 (ＣＹＰ)基因的多态性是遗传调查的另一目标 ,这些等位基因在编码一些酶具有重要作用 ,这些酶可以代谢一系列包括有机溶剂和药物在内的化合物。这些基因包括ＣＹＰ2Ｅ1(对有机溶剂的代谢有
An individual with an HLA DR7 allele is more susceptible to scleroderma than an individual without this allele. Polymorphism of cytochrome P450 (CYP) genes is another genetic investigation that plays an important role in the coding of enzymes that metabolize a range of compounds, including organic solvents and drugs. These genes include CYP2E1 (metabolism of organic solvents