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目的观察甘精胰岛素联合西格列汀治疗2型糖尿病的有效性及安全性。方法将2型糖尿病患者90例随机分为观察组和对照组各45例。观察组给予甘精胰岛素联合西格列汀治疗,对照组给予甘精胰岛素治疗,治疗6周后比较两组患者治疗前后糖化血红蛋白(HbA1c)、餐后2h血糖(2hPG)、空腹血糖(FBG)水平及临床疗效。结果两组患者治疗后观察组总有效率为86.7%,高于对照组的71.1%(P<0.05);且治疗后HbA1c、2hPG、FBG水平均下降(P<0.05),且观察组下降更显著,差异有统计学意义(P<0.05)。结论甘精胰岛素联合西格列汀患者依从性好,低血糖事件发生率低,能有效地控制血糖,是一种较为理想联合治疗方法。
Objective To observe the efficacy and safety of insulin glargine and sitagliptin in the treatment of type 2 diabetes. Methods 90 patients with type 2 diabetes were randomly divided into observation group and control group, 45 cases each. The observation group was treated with glargine and sitagliptin, the control group was given insulin glargine, and the levels of HbA1c, 2hPG, FBG, Level and clinical efficacy. Results After treatment, the total effective rate of observation group was 86.7%, which was higher than that of control group (71.1%, P <0.05), and the levels of HbA1c, 2hPG and FBG decreased (P <0.05) Significantly, the difference was statistically significant (P <0.05). Conclusion Glargine and sitagliptin have good compliance and low incidence of hypoglycaemia, which can effectively control blood sugar. It is an ideal combination therapy.