Roles of cell fusion,hybridization and polyploid cell formation in cancer metastasis

• 作 者: Ivan Shabo Joar Svanvik Anneli
• 机 构: EndocrineandSarcomaSurgeryUnit,PatientAreaofBreastCancer,TheTransplantInstitute,DivisionofSurgery,Di
• 出 处: 世界临床肿瘤学杂志(英文版)
• 发表日期: 2020年3期
• 关键词: Cell fusion Hybrid formation POLYPLOIDIZATION MACROPHAGE Cancer PROGRESSION Onco

Cell-cell fusion is a normal biological process playing essential roles in organ formation and tissue differentiation,repair and regeneration.Through cell fusion somatic cells undergo rapid nuclear reprogramming and epigenetic modifications to form hybrid