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人类开始衰老即伴随着空间学习记忆能力的损害.人们巳用多样方法证实老年大鼠也有空间学习记忆能力障碍.且在人和鼠均显示明显的年龄相关的海马结构改变.本实验选用大鼠作模型研究老年性学习记忆能力改变,为研究老年性学习记忆的神经生物学提供一个较理想的模型.实验动物分青年(3月)、老年(24月)两组.检验装置是在Morris水迷宫的基础上加以改进,整个实验过程分为学习(Shaping)直线游泳(SS)、位置识别(PD)和重复获取(RA)等阶段.学习的过程是训练实验鼠在水中通过爬上平台而逃避水难.SS过程是
Aging has been associated with impairment of spatial learning and memory in humans, and various mechanisms have been used to confirm that older rats also have spatial learning and memory impairments, and age-related changes in the structure of the hippocampus have been shown in both humans and mice.In this study, rats As a model to study changes in the learning and memory ability of senile people, to provide an ideal model for studying the neurobiology of senile learning and memory.The experimental animals were divided into two groups: young (March) and old (24 months) The maze is improved on the basis of the experiment, the whole experiment is divided into Shaping (SS), position recognition (PD) and repetitive acquisition (RA) etc. The learning process is to train the rats in the water by climbing the platform Escape from water .SS process is