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对脾虚证动物模型的制作思路和方法进行了比较。1.中医“证”的动物制模有别于西医病理模型。2.根据导致脾虚证的多种病因而采用多种造模方法,同时又结合脾虚证的统一标准衡量复制出的模型的一致性、可靠性,并进行药物反证,体现了造模方法的不同性与证明同一性相结合。3.不同的造模方法反映不同的病理机制:如大黄、番泻叶等苦寒之品制模系“大泻伤脾”、“苦寒伤脾”的因泻致虚;以利血平等制模则为因虚致泻;而虚证模型(如阳虚模型、阴虚模型等)虚而不泻则与具有泄泻的脾虚证模型有区别。
The author made a comparison of the thinking and methods of animal model of spleen deficiency. 1. TCM “card” animal model is different from Western pathological model. 2. According to a variety of causes leading to spleen deficiency syndrome using a variety of modeling methods, combined with the unified standard spleen deficiency syndrome replicate the model to measure the consistency, reliability, and anti-evidence of the drug, reflects the different modeling methods and Proof of identity combined. 3. Different modeling methods reflect different pathological mechanisms: such as rhubarb, senna and other bitter cold products modeling system, “diarrhea, spleen injury,” “Bitter injury spleen” due to diarrhea caused by virtual; reserpine model is Due to the virtual diarrhea; and deficiency syndrome model (such as yang deficiency model, yin deficiency model, etc.) but not diarrhea with diarrhea spleen deficiency syndrome model difference.