平阳霉素局部注射治疗眼部血管瘤

• 作 者: 赵庆新 陈 刘慧荣 刘宏 王燕燕 郎玉静
• 机 构: 河南省新乡市中心医院眼科!453000,河南省新乡市中心医院眼科!453000,河南省新乡市中心医院眼科!453000,河南省新乡市中心医院眼科!453000,河南省新乡市中心医院眼科!453000,
• 出 处: 眼科新进展
• 发表日期: 1998年03期
• 关键词: 血管瘤 局部注射治疗 皮试针头 内皮增生 抑制细胞 作用机理 血管闭塞 瘤体内注射 多卡因 后瘤

目的探讨平阳霉素治疗眼部血管瘤的疗效、作用机理及治疗时机。方法平阳霉素10mg（粉剂）溶于10g·L-1利多卡因或生理盐水3～5ml中，皮试针头直接刺入瘤体内注药，以注药后瘤体变苍白肿胀为宜。对瘤体较大或多发者可分次注药，每次间隔7～10d。结果治疗19例，特效8例，显效11例，治愈率100％。结论平阳霉素可迅速抑制细胞内皮增生，使血管闭塞萎缩，血液供应不足，从而使血管瘤消退。治疗过程中未发现任何不良反应及副作用。

Objective To investigate the curative effect, mechanism and timing of treatment of ocular hemangioma with Pingyangmycin. Methods Pingyangmycin 10mg (powder) was dissolved in 10g · L-1 lidocaine or normal saline 3 ~ 5ml, the skin test needle directly into the tumor instillation, after injection of tumor pale swelling is appropriate. For large or multiple tumors can be sub-injection, each interval of 7 ~ 10d. Results 19 cases of treatment, 8 cases of special effects, markedly effective in 11 cases, the cure rate was 100%. Conclusion Pingyangmycin can rapidly inhibit endothelial cell proliferation, vascular occlusion atrophy, lack of blood supply, so that hemangiomas subsided. No adverse reactions and side effects were found during the treatment.