Distinct Effects of Social Stress on Working Memory in Obsessive-Compulsive Disorder

• 作 者: Qianqian Li Jun Yan Jinmin Liao Xiao Zhang Lijun Liu Xiaoyu Fu Hao Yang Tan Dai Zhang Hao Yan
• 机 构: Peking University Sixth Hospital, Beijing 100191, China;Peking University Institute of Mental Health
• 出 处: 神经科学通报（英文版）
• 发表日期: 2021年1期
• 关键词: Working memory Acute stress Obsessive-compulsive disorder Functional magnetic re

Stress might exaggerate the compulsion and impair the working memory of patients with obsessive-compulsive disorder(OCD).This study evaluated the effect of stress on the cognitive neural processing of working memory in OCD and its clinical significance using a“number calculation working memory”task.Thirty-eight patients and 55 gender-and education-matched healthy controls were examined.Stress impaired the performance of the manipulation task in patients.Healthy controls showed less engagement of the medial prefrontal cortex and striatum during the task under stress versus less stress,which was absent in the patients with OCD.The diagno-sis x stress interaction effect was significant in the right fusiform,supplementary motor area,precentral cortex and caudate.The failure of suppression of the medial prefrontal cortex and striatum and stress-related hyperactivation in the right fusiform,supplementary motor area,precentral cortex,and caudate might be an OCD-related psychopatho-logical and neural response to stress.