Thermomineral water promotes axonal sprouting but does not reduce glial scar formation in a mouse mo

• 作 者: Dubravka Aleksi Milan Aksi Nevena Divac Vidosava Radonji Branislav Filipovi Igor Jakovevski
• 机 构: Institute of Anatomy“Niko Miljani?”, Faculty of Medicine, University of Belgrade, Belgrade, Serbia“,
• 出 处: 中国神经再生研究（英文版）
• 发表日期: 2014年24期
• 关键词: astrocyte scar catecholaminergic innervations lithium magnesium thermomineral wa

Thermomineral water from the Atomic Spa Gja Trep?a has been used for a century in the treatment of neurologic disease. The thermomineral water contains microelements, including lithium and magnesium, which show neural regeneration-promoting effects after central nervous system injury. In this study, we investigated the effects of oral intake of thermomineral water from the Atomic Spa Gja Trep?a on nerve regeneration in a 3-month-old mouse model of spinal cord injury. The mice receiving oral intake of thermomineral water showed better locomo-tor recovery than those without administration of thermomineral water at 8 and 12 weeks after lower thoracic spinal cord compression. At 12 weeks after injury, sprouting of catecholaminergic axons was better in mice that drank thermomineral water than in those without administration of thermomineral water, but there was no difference in glial reaction to injury between mice with and without administration of thermomineral water. These ifndings suggest that thermomineral water can promote the nerve regeneration but cannot reduce glial scar formation in a mouse model of spinal cord injury.