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本文以ＯＶＸ大鼠为动物模型，观察了去势１５天、３０天和６０天大鼠血清甲状旁腺激素（ＰＴＨ）和降钙素（ＣＴ）含量，第６胸椎（Ｔ６），第３腰椎（Ｌ３）和股骨矿盐含量及骨力学参数的变化。实验结果表明，去势１５天、３０天和６０天大鼠血清ＣＴ显著降低，去势３０天和６０天大鼠血清ＰＴＨ显著降低。去势１５天大鼠Ｔ６横截面积显著降低，去势６０天大鼠Ｔ６类骨质含量显著增加。去势１５天和３０天大鼠Ｌ３矿盐含量显著降低，３０天骨压缩强度显著降低，６０天最大应力、杨氏模量显著降低，横截面积显著增加。去势１５天和３０天大鼠股骨弯曲应力、张应力显著降低，弹性能密度在３０天显著降低，去势６０天股骨近１／３部位矿盐含量显著降低。实验结果提示，ＯＶＸ大鼠ＣＴ降低是引起骨质丢失、骨力学性能低下的一个重要因素。松质骨骨丢失早于皮质骨，但力学性能的降低晚于皮质骨，ＯＶＸ大鼠骨有机质减少是非胶原蛋白减少。ｐ＜０．０１从表１可知，与对照组比较，去势１５天大鼠Ｔ６骨横截面积显著降低，去势３０天大鼠股骨干横截面积显著增加，去势６０天大鼠Ｌ３截面积显著增加。去势３０天和６０天大鼠血清ＰＴＨ显著降低。去势１５天、３０天和６０天大鼠血清ＣＴ均显著降低。２．２两?
In this paper, OVX rats were used as animal models to observe the changes of serum parathyroid hormone (PTH) and calcitonin (CT) levels, the 6th thoracic vertebra (T6), the 3rd lumbar vertebra (L3) and femoral mineral salt content and bone mechanics parameters. The experimental results showed that serum CT of the rats at 15 days, 30 days and 60 days after castration was significantly decreased, and the serum PTH was significantly decreased at 30 days and 60 days after castration. The cross-sectional area of T6 in ovariectomized 15-day rats was significantly decreased, and the content of T6 in rat ovariectomized 60 days was significantly increased. After 15 days and 30 days of castration, the content of salt in L3 was significantly decreased, the bone compressive strength decreased significantly at 30 days, the maximum stress at 60 days, the Young’s modulus decreased significantly, and the cross-sectional area increased significantly. At 15 days and 30 days after castration, the bending stress and tensile stress of the femur decreased significantly, the elastic energy density decreased significantly at 30 days, and the mineral content of the proximal 1/3 part of castrated 60 days significantly decreased. The experimental results suggest that the reduction of CT in OVX rats is an important factor that causes bone loss and low bone mechanical properties. Loss of cancellous bone was earlier than that of cortical bone, but the reduction of mechanical properties was later than that of cortical bone. Reduction of bone organic matter in OVX rats was a reduction of non-collagenous protein. p <0.01 It can be seen from Table 1, compared with the control group, the castrated 15-day rat T6 bone cross-sectional area was significantly reduced castrated 30-day rat femoral shaft cross-sectional area was significantly increased, ovariectomized 60 days rat L3 Cross-sectional area increased significantly. Serum PTH was significantly decreased in castrated rats at 30 days and 60 days. Serum CT was significantly reduced in castrated rats at days 15, 30 and 60. 2.2 two?