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通过对ICU重症感染患者PCT监测,指导抗菌药物使用,评估治疗疗效。方法 :选择2014年1月至2015年12月在苏州市中西医结合医院ICU住院的重症感染患者72例,按随机数字表法分为常规抗菌药物治疗组(RAT组,36例)及PCT监测指导抗菌药物治疗组(PCT组,36例).RAT组按重症感染的抗菌药物治疗原则选择及停用抗菌药物;PCT组在此基础上每天监测PCT,指导抗生素使用。对比分析两组降钙素原含量,抗生素使用时间,治愈率,ICU住院时间。结果 :PCT组降钙素原含量(0.37±0.06)ng/ml vs对照组(0.58±0.11)ng/ml,差异具有统计学意义(p<0.05);PCT组抗生素使用时间(6.7±1.1)d、ICU住院时间(13.4±2.3)d均短于对照组(9.8±1.7)d、(18.5±2.7)d,差异有统计学意义(p<0.05)。结论 :通过对PCT监测即使调控抗生素使用,对重症感染患者有重要意义,相比常规用药,可以有效减少药物使用时间,提高疗效,缩短住院时间。
Through the ICU severe infection in patients with PCT monitoring, guidance on the use of antimicrobial agents to assess the efficacy of treatment. Methods: From January 2014 to December 2015, 72 patients with severe infections hospitalized in the ICU of Suzhou Hospital of Integrated Traditional Chinese and Western Medicine were randomly divided into routine antimicrobial treatment group (RAT group, 36 cases) and PCT monitoring Guide the antimicrobial treatment group (PCT group, 36 cases) .RAT group according to the principle of antimicrobial treatment of severe infection selection and discontinuation of antimicrobial agents; PCT group on the basis of daily monitoring of PCT, to guide the use of antibiotics. Comparative analysis of two groups of procalcitonin content, antibiotic use time, cure rate, ICU hospital stay. Results: The PCT level of procalcitonin was (0.37 ± 0.06) ng / ml vs control group (0.58 ± 0.11) ng / ml, the difference was statistically significant (p <0.05) d, ICU hospital stay (13.4 ± 2.3) d were shorter than the control group (9.8 ± 1.7) d, (18.5 ± 2.7) d, the difference was statistically significant (p <0.05). CONCLUSION: Even though the regulation of antibiotics use in PCT monitoring is of great significance to patients with severe infections, compared with conventional medication, it can effectively reduce the drug use time, improve the curative effect and shorten the hospitalization time.