Retroviral integrase protein and intasome nucleoprotein complex structures

• 作 者: Julia Grawenhoff Alan N Engelm
• 机 构: DepartmentofCancerImmunologyandVirology,DepartmentofMedicine
• 出 处: 世界生物化学杂志：英文版（电子版）
• 发表日期: 2017年1期
• 关键词: DNA 集成 3-dimensional 结构 INTEGRASE Intasome 老鼠乳房的肿瘤病毒 RETROVIRUS Rous 肉瘤病毒 为起泡沫的病
• 基金项目: Supported by United States National Institutes of Health grant,No.R01AI070042

Retroviral replication proceeds through the integration of a DNA copy of the viral RNA genome into the host cellular genome, a process that is mediated by the viral integrase(IN) protein. IN catalyzes two distinct chemical reactions: 3’-processing, whereb