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支气管哮喘(简称哮喘)是由多种细胞和细胞组分参与的慢性炎症性疾病。既往认为嗜酸粒细胞(eosinophil,EOS)为哮喘的主要炎症细胞。近年来,大量研究证实中性粒细胞(neutrophil,NEU)在哮喘的发生、发展中起着重要作用。Douwes等~([1])发现约50%的哮喘是由NEU引起,且NEU与重症哮喘~([2])、迟发型哮喘~([3])、激素不敏感型哮喘~([4])等密切相关。2006年Simpson等~([5])将诱导痰中中性粒细胞百分比(NEU%)>61%的哮喘患者列为哮喘的一个独
Bronchial asthma (referred to as asthma) is a chronic inflammatory disease involving a variety of cells and cellular components. Past eosinophil (eosinophil, EOS) as the main inflammatory cells of asthma. In recent years, a large number of studies have demonstrated that neutrophil (NEU) plays an important role in the development and progression of asthma. Douwes et al. (1) found that about 50% of asthma is caused by NEU and that NEU is associated with severe asthma ~ (2), delayed asthma ~ (3), hormone insensitive asthma ~ (4 ]) Are closely related. In 2006, Simpson et al. ([5]) classified asthma with a> 65% neutrophil percentage (NEU%) in sputum as a single agent of asthma