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目的:观察Ｇｒａｖｅｓ病患者治疗前后ｓＩＬ－２Ｒ和ＴＲＡｂ水平的变化，指导临床用药及监测病清。方法；分别应用酶联法检测Ｇｒａｖｅｓ病患者治疗前后及对照组外周血ｓＩＬ—２Ｒ和ＴＲＡｂ，用放射免疫法测定Ｔ４、Ｔ３，并比较其变化。结果：Ｇｒａｖｅｓ病患者治疗前血ｓＩＬ—２Ｒ和ＴＲＡｂ水平明显高于治疗后及正常对照组，并且二者均与Ｔ４、Ｔ３水平呈正相关。结论：监测外周血ｓＩＬ—２Ｒ和ＴＲＡｂ水平对于Ｇｒａｖｅｓ病患者的治疗及预后分析有着重要意义。
OBJECTIVE: To observe the changes of sIL-2R and TRAb levels in patients with Graves’ disease before and after treatment, to guide clinical medication and to monitor the disease status. Methods Serum levels of sIL-2R and TRAb in peripheral blood of patients with Graves’ disease before and after treatment and control group were detected by ELISA. T4 and T3 were measured by radioimmunoassay and their changes were compared. Results: The serum levels of sIL-2R and TRAb in patients with Graves disease before treatment were significantly higher than those in the controls and normal controls, and both were positively correlated with T4 and T3 levels. Conclusion: Monitoring the levels of sIL-2R and TRAb in peripheral blood is of great significance for the treatment and prognosis of patients with Graves’ disease.