,Overexpression of SIRT3 disrupts mitochondrial proteostasis and cell cycle progression

• 作 者: Xiaofei Wang Haiping Tang Yuling Chen Binghuan Chi Shiyu Wang Yang Lv Di Wu
• 机 构: MOE Key Laboratory of Bioinformatics, School of Life Sciences,Tsinghua University, Beijing 100084, C
• 出 处: 蛋白质与细胞
• 发表日期: 2016年4期

Dear Editor,As a mitochondrial deacetylase,SIRT3 deacetylates many enzymes involved in central metabolism and maintains mitochondrial proteostasis (Verdin et al.,2010;Papa and Germain,2014).Substrates of SIRT3 include components of the respiratory complexes,proteins involved in fatty acid oxidation and TCA cycle (Yu et al.,2012).