【摘 要】
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Dear Editor,Several recent clinical studies have indicated that dietary supplementation with branched-chain amino acids (BCAA),particularly with leucine,is an e
【机 构】
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College of Life Science, University of Chinese Academy of Sciences, Beijing 100049, China“,”National
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Dear Editor,Several recent clinical studies have indicated that dietary supplementation with branched-chain amino acids (BCAA),particularly with leucine,is an effective anti-atrophic therapy (Bauer et al.,2015;Tsien et al.,2015;English et al.,2016).In animal models,BCAA can prevent denervation (Ribeiro et al.,2015),hindlimb suspension (Maki et al.,2012;Jang et al.,2015) or dexamethasone-induced (Yamamoto et al.,2010) muscle atrophy.General control nonderepressible 2 kinase (GCN2) is a well-known amino-acid sensor.Under conditions of amino-acid deprivation,the increased level of uncharged transfer RNA (tRNA) activates GCN2 through binding to the histadyl-tRNA synthetase-like domain (Wek et al.,1995).
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