论文部分内容阅读
目的探索新技术、新工艺在中药加工方面的应用,为治疗皮肤瘙痒性疾病提供药物新剂型。方法将符合质量标准的原料药材(包括苍耳子、地肤子、川芎、红花和白英)通过专业设备加工成微粉剂——“痒可消”并对其外观及粒度分布进行技术检测;并观察它对醋酸注射小鼠腹腔所致毛细管通透性增高、二甲苯所致的小鼠耳壳肿胀、磷酸组胺所致豚鼠致痒阈的影响;用小鼠进行急性毒性实验。结果“痒可消”外观颗粒均匀,手感细腻,口服颗粒感不明显,且全部粒径均小于47μm。药效学研究表明:“痒可消”能明显抑制醋酸所致小鼠腹腔毛细血管通透性增高;减轻二甲苯所致的小鼠耳壳肿胀;提高磷酸组胺所致豚鼠致痒阈。小鼠急性毒性试验显示:所有试验小鼠无一死亡,生长发育正常,主要脏器未见异常,最大耐受量为成人一日用量的114.09倍。结论“痒可消”确为微米级中药;本品抗炎止痒作用明显,具有用量少、疗效高的特点,临床应用较为安全可靠,可针对性地用于皮肤瘙痒性疾病,对简化传统剂型的前处理工艺流程、节约资源、降低用药成本及中药事业的持续发展都具有重要的意义。
Objective To explore the application of new technology and new technology in the processing of traditional Chinese medicine and to provide new drug formulations for the treatment of pruritic skin diseases. Methods The raw materials (including Xanthium sibiricum, Rhubarb, Rhizoma chuanxiong, safflower, and Baiying), which meet the quality standards, were processed into micronized powder - “itch counteracting” through professional equipment, and its appearance and particle size distribution were detected technically ; And observe its impact on acetic acid injection mouse peritoneal capillary permeability increased, xylene-induced mice ear swelling, histamine induced guinea pig induced itch threshold; mice acute toxicity test. Results “Itch can eliminate” the appearance of uniform particles, feel fine, oral particle is not obvious, and all the particle size is less than 47μm. Pharmacodynamic studies have shown that “itch can eliminate” can significantly inhibit acetic acid-induced increased peritoneal capillary permeability; reduce xylene-induced ear swelling in mice; and improve histamine induced guinea pig induced itch threshold. Acute toxicity test in mice showed that none of the mice died, their growth and development were normal, no abnormality was found in the main organs, and the maximum tolerated dose was 114.09 times of the daily dose for adults. Conclusion “Itch can eliminate” is indeed micron Chinese medicine; This product is anti-inflammatory anti-itch effect is obvious, with less dosage, high efficacy, clinical application is more safe and reliable, can be targeted for pruritic skin diseases, to simplify Traditional dosage forms of pre-treatment process, save resources, reduce the cost of medication and the sustained development of Chinese medicine are of great significance.