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目的:研究DNA 含量与滑膜肉瘤预后的关系。方法:采用流式细胞术对52 例滑膜肉瘤中的DNA 含量进行分析。结果:52 例滑膜肉瘤中44 例为异倍体,异倍体检出率为84.6 % 。异倍体的检出率与滑膜肉瘤患者术后3 年生存率呈明显负相关( P< 0.05) ,其与淋巴转移、骨侵袭及肺转移呈明显正相关( P< 0.05) 。结论:DNA 含量可作为判定滑膜肉瘤患者预后的一个理想指标。
Objective: To study the relationship between DNA content and prognosis of synovial sarcoma. Methods: Fifty-two cases of synovial sarcoma DNA were analyzed by flow cytometry. RESULTS: Of the 52 cases of synovial sarcoma, 44 were aneuploid and the heteroploid detection rate was 84.6 %. The detection rate of aneuploids was negatively correlated with the 3-year survival rate of patients with synovial sarcoma (P<0.05), and it was positively correlated with lymphatic metastasis, bone invasion, and lung metastasis (P<0.05). ). Conclusion: DNA content can be used as an ideal indicator to determine the prognosis of patients with synovial sarcoma.