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约在一个世纪前,Jackson首先提出皮质源性癫痫是由一放电损害引起,此种损害先引起局部发作,然后再扩散到脑的其余部份,使正常神经元环路产生继发性活化的理论。皮质源性癫痫的发作是从一个癫痫病灶开始,病灶内具有自发产生高爆发电活动的病理细胞(Highly explosive cells),当其爆发放电时,可使邻近正常神经元发生继发性激化,产生同步过度放电而爆发癫痫。目前已知导致癫痫自发发作所必须的癫痫神经元是多个的,但其临界数量是多少尚不清楚。癫痫神经元的放电形式有二:一种为周期性高频
About a century ago, Jackson first proposed that cortical-derived epilepsy is caused by a discharge injury that first causes a local attack and then spreads to the rest of the brain, resulting in secondary activation of the normal neuronal circuits theory. The onset of cortical-derived epilepsy begins with an epileptic lesion with highly-explosive cells spontaneously producing highly explosive electrical activity that, when triggered by an electrical discharge, can produce secondary intensification of adjacent normal neurons Synchronous over-discharge epilepsy. It is known that there are many epileptic neurons that are necessary for the spontaneous seizures. However, it is not clear how much of the critical number is. There are two types of discharge in epileptic neurons: one is periodic high frequency