Protracted anaphylaxis developed after peginterferon α-2a administration for chronic hepatitis C

• 作 者: Akihiko Sakatani Yoshinori Doi Takaaki Matsuda Yasutaka Sasai Naohiro Nishida Megumi Sakamoto Naoto Uenoyama Yoshiya Matsumoto Kazuo Kinoshita
• 机 构: Department of Gastroenterology and Hepatology,Osaka University Graduate School of Medicine,Suita,Osa
• 出 处: World Journal of Gastroenterology
• 发表日期: 2015年09期
• 关键词: administration nausea recognize suffered extremely headache outpatient threateni

Peginterferon is a key drug used to treat chronic viral hepatitis that is known for causing various side effects.Side effects occurring immediately after administration include headache, nausea, and influenza-like symptoms, such as fever and joint pain.However, reports of anaphylactic shock are extremely rare.Here we report a patient with protracted anaphylaxis who suffered shock symptoms after peginterferon α-2a administration for chronic hepatitis C.Although the patient improved temporarily with shock treatment, symptoms of anaphylaxis recurred.As peginterferon is often administered on an outpatient basis, it is important to recognize life-threatening side effects that may develop in a protracted manner.

Peginterferon is a key drug used to treat chronic viral hepatitis that is known for for various side effects. Side effects occurred immediately after administration include headache, nausea, and influenza-like symptoms, such as fever and joint pain. However, reports of anaphylactic shock are extremely rare. Here we report a patient with protracted anaphylaxis who suffered shock symptoms after peginterferon α-2a administration for chronic hepatitis C. Although the patient improved temporarily with shock treatment, symptoms of anaphylaxis recurred. As peginterferon is often administered on an outpatient basis , it is important to recognize life-threatening side effects that may develop in a protracted manner.