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目的分析肝素防治紫癜性肾炎的临床效果。方法将2009年3月-2012年3月我院过敏性紫癜患者104例分为两组各52例,观察组接受抗过敏、血管改善等基础治疗的同时,静脉输注低分子肝素,对照组仅给与基础治疗,观察比较两组临床效果。结果观察组患者皮疹消退时间和关节肿痛消退时间明显好于对照组;观察组治疗后半年肾炎发生率、肾炎平均发生时间均优于对照组(P<0.05);两组患者均未出现严重不良反应。结论肝素利于过敏性紫癜的治疗,降低了紫癜性肾炎发生率,临床效果显著,安全性较好,值得临床借鉴。
Objective To analyze the clinical effect of heparin on purpuric nephritis. Methods 104 cases of allergic purpura in our hospital from March 2009 to March 2012 were divided into two groups of 52 cases. The observation group received basic therapy such as anti-allergy and blood vessel improvement. At the same time, low molecular weight heparin and control group Only give basic treatment, observe the clinical effect of two groups. Results The edema time of the rash in the observation group and the subsided time of joint pain were significantly better than those in the control group. The incidence of nephritis and the average incidence of nephritis in the observation group were all better than those in the control group (P <0.05) Adverse reactions. Conclusions Heparin is beneficial to the treatment of Henoch-Schonlein purpura and reduces the incidence of purpura nephritis. The clinical effect is significant, and the safety is better, which is worthy of clinical reference.