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目的观察奥美拉唑联合铝碳酸镁治疗胆囊切除术后伴胆汁反流性胃炎的临床效果。方法将240例胆囊切除术后伴胆汁反流性胃炎患者随机分为研究组和对照组各120例。对照组单独给予铝碳酸镁治疗,研究组在对照组基础上给予奥美拉唑治疗。结果研究组总有效率为96.7%明显高于对照组的78.3%,治疗后2组临床症状评分均显著下降,且研究组低于对照组,差异均有统计学意义(P<0.01或P<0.05)。2组不良反应发生率比较差异无统计学意义(P>0.05)。结论在对胆囊切除术后伴胆汁反流性胃炎的治疗中,奥美拉唑联合铝碳酸镁能快速改善患者临床症状,提高临床疗效,且安全性较高,不良反应较轻,具有重要临床价值。
Objective To observe the clinical effects of omeprazole and magnesium aluminum carbonate in the treatment of bile reflux gastritis after cholecystectomy. Methods A total of 240 patients with bile reflux gastritis after cholecystectomy were randomly divided into study group and control group with 120 cases each. The control group was given magnesium aluminum carbonate alone, and the study group was given omeprazole on the basis of the control group. Results The total effective rate was 96.7% in the study group, which was significantly higher than 78.3% in the control group. The clinical symptom scores of the two groups were significantly decreased after treatment, and the study group was lower than the control group, the difference was statistically significant (P <0.01 or P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusions Omeprazole combined with aluminum magnesium carbonate can rapidly improve clinical symptoms and improve clinical efficacy in patients with bile reflux gastritis after cholecystectomy. It is safe and has mild adverse reactions and has important clinical significance value.