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脑内单胺含量上升时,痉挛发作的阈值提高;癫痫患者脑内单胺的代谢似存在异常。这些都说明癫痫发作与单胺具有某种关系。某些抗癫痫药的抗痉挛作用随脑内单胺浓度而改变,其中受脑内单胺影响最大的是碳酸酐酶抑制剂,如甲酰唑胺的抗痉挛作用,可因事前以利血平处理而被消除。作者研究了利血平使之耗竭的单胺中哪一个与此直接有关。甲酰唑胺的抗痉挛作用可被肾上腺素能阻断剂所拮抗,但可被苯丙胺、丙咪嗪或苯环丙胺所增强,故认为其抗痉挛作用与儿茶酚胺有关。甲酰唑胺的作用可因给予异丙异烟肼或DL-多巴而恢复,DL-
Brain monoamine content increased, the threshold for seizures increased; monoamine metabolism in patients with epilepsy there is an abnormality. All of these show that seizures have some relationship with monoamines. Some antiepileptic drugs antispasmodic effect with the concentration of monoamine concentration in the brain changes, which is most affected by monoamine in the brain is carbonic anhydrase inhibitors, such as the role of formoxazole anti-spasm, may be due to pre-Yi Li Flattened and eliminated. The authors looked at which of the monoamines that are depleted by reserpine is directly related to this. The anti-spasm effect of formoxazole can be antagonized by adrenergic blockers, but can be amphetamine, imipramine or benzene cyclopropylamine enhanced, so that its antispasmodic effect and catecholamines. The effect of formoxazol can be restored by administration of Isoprenaline or DL-dopa, and DL-