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Lammler氏等(1978)曾用感染棉鼠丝虫的纳塔耳多乳头鼠筛选到呋喃唑酮(痢特灵)25～75mg/kg有杀成虫效果,但此剂量可能对人体有毒性。鉴于以往研究的结果,抗纳塔耳多乳头鼠体内的棉鼠丝虫远较抗棉鼠体内的棉鼠丝虫所需剂量为大。本文作者为探索适合于临床试验的剂量,对呋喃唑酮抗棉鼠体内棉鼠丝虫的有效剂量进行了研究。以尾血中微丝蚴密度为250条/5cmm的棉鼠为实验,每组5鼠,用1%吐温-80无菌溶液配制呋喃唑酮悬液,按45mg/kg、15mg/kg及5mg/kg腹腔注射或15mg/kg、5mg/kg口服,连续给药6天,共分5组,并设对照。结果:腹腔注射给药的3组动物,在治疗后第4、8、14天作血的微丝蚴计数均无明显变化,至第21天血的微丝蚴数显著减少。至42天时,45mg/kg组的血内微丝蚴较治前
Lammler’s et al. (1978) used an injection of furazolidone (furazolidone) 25 to 75 mg / kg to kill adult worms in Natalian nipples infected with the silkworm, but this dose may be toxic to humans. In view of the results of previous studies, fibromonas in the anti-Natal polygamy mice are much larger than the doses required for the resistance of cotton rats to cotton bollworms in cotton rats. In order to explore the dose suitable for clinical trials, the authors studied the effective dose of furazolidone against cotton rats in vivo. Tail blood Microfilaria density of 250 / 5cmm cotton rats for the experiment, each group of 5 rats, with 1% Tween-80 sterile solution preparation of furazolidone suspension, according to 45mg / kg, 15mg / kg and 5mg / kg intraperitoneal injection or 15mg / kg, 5mg / kg orally, continuous administration of 6 days, divided into 5 groups, and set the control. Results: There were no significant changes in counts of blood microfilariae on the 4th, 8th and 14th days after treatment in the three groups of animals injected intraperitoneally. The number of microfilariae of blood was significantly reduced on the 21st day. At day 42, the intramuscular microfilaria in the 45 mg / kg group was more pre-treatment