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Rb基因是细胞生长分化的重要调控因子。我们应用S－P免疫组织化学方法研究Rb基因产物表达与胃癌临床病理学特声、和预后的关系。本组胃癌Rb基因产物阳性表达为62／85（72．94％），与淋巴结转移呈极显著性正相关（P＜0．01），与胃癌术后生存期呈极显著性负相关（P＜0．01）。Rb基因产物阳性级别高者，易发生淋巴结转移，生存期可能较短。检测Rb基因产物表达有助于胃癌生极学行为的认识及预后判断。
Rb gene is an important regulator of cell growth and differentiation. We used S-P immunohistochemistry to study the relationship between the expression of Rb gene products and the clinical pathology of gastric cancer, and the prognosis. The positive expression of Rb gene product in this group was 62/85 (72.94%), which was significantly positively correlated with lymph node metastasis (P<0.01), and was significantly negatively correlated with postoperative survival of gastric cancer (P <0.01). Those with high positive levels of Rb gene products are prone to lymph node metastasis and may have a shorter survival period. Detecting the expression of Rb gene product contributes to the understanding of the biologic behavior of gastric cancer and its prognosis.