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缬氨酸杀虫菊酯是一类很有发展前景的杀虫杀螨剂，它的菊酸部分为Ｒ－构型，菊醇部分为Ｓ－构型，其合成是由相应的缬氨酸或者它的活性衍生物与相应的醇经酯化而制得。具体过程是Ｄ－缬氨酸经６ＮＨＢｒ／ＮａＮＯ２溴化制成（Ｒ）－α－溴代异戊酸，再与对三氟甲基苯胺反应合成（Ｒ）－Ｎ－［（４－三氟甲基）苯基］α－缬氨酸，后被Ｎ－氯代琥珀酰亚胺氯化制成（Ｒ）－Ｎ－［２－氯－４－（三氟甲基）苯基］α－缬氨酸，最后与（Ｓ）－α－氰基－３－苯氧苯基甲醇用ＤＣＣ脱水酯化合成缬氨酸杀虫菊酯Ｉ（Ｒ１＝Ｆ３Ｃ，Ｒ２＝Ｈ，ＣＬ，Ｒ３＝Ｈ）。还给出了两种菊酯２×４种异构体杀虫（烟草夜蛾和家蝇）活性数据。
The valine pyrethroid is a very promising insecticide and acaricide, its chrysanthemum part is R-configuration and the chrysanthemum part is S-configuration, and its synthesis is based on the corresponding valine Or its reactive derivative with the corresponding alcohol by esterification and prepared. The specific process is that D-valine is brominated with 6NHBr / NaNO2 to obtain (R) -α-bromoisovalerate, and then reacted with trifluoromethylaniline to synthesize (R) -N - [(4- Methyl) phenyl] a-valine, followed by chlorination with N-chlorosuccinimide to give (R) -N- [2-chloro-4- (trifluoromethyl) phenyl] Valine and finally with (S) -α-cyano-3-phenoxyphenylmethanol by dehydration with DCC to synthesize valine pyrethroid I (R1 = F3C, R2 = H, CL, R3 = H ). Also provided are 2 insecticidal (tobacco budworm and housefly) activity data for 2 * 4 isomers of pyrethrins.