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目的探讨血清中IL-10和中性粒细胞CD64含量与原发性肾病综合患者激素治疗效果及并发症的关系。方法选择2015年9月-2016年9月60例原发性肾病综合征的患者为研究对象,均采用激素治疗,检测患者血清中IL-10和CD64细胞含量水平与肾病综合征治疗效果及临床并发症的关系。结果 IL-10和中性粒细胞CD64高水平组和低水平组患者血清中血肌酐、白蛋白、尿白蛋白以及病理类型比较,差异均无统计学意义(P>0.05);激素抵抗的患者IL-10、CD64表达高于激素敏感和激素依赖,差异有统计学意义(P<0.05)。Logistic回归模型分析提示,IL-10(P<0.05)、中性粒细胞CD64(P<0.05)、病理类型(P<0.05)是患者发生慢性肾功能不全的独立危险因素。结论血清中IL-10和中性粒细胞CD64水平与肾病综合征患者激素治疗效果及肾病综合征激素治疗效果密切相关。
Objective To investigate the relationship between the serum levels of IL-10 and neutrophil CD64 in patients with primary nephrotic syndrome and the effects of hormone therapy. Methods Sixty patients with primary nephrotic syndrome from September 2015 to September 2016 were enrolled in this study. All of them were treated with hormonal therapy to detect the level of IL-10 and CD64 in the serum of patients with nephrotic syndrome and the clinical effects The relationship between complications. Results The serum levels of serum creatinine, albumin, urinary albumin and pathological types of IL-10 and neutrophil CD64 high and low groups were not significantly different (P> 0.05). Patients with hormone resistance The expression of IL-10 and CD64 was higher than that of hormone-sensitive and hormone-dependent, with statistical significance (P <0.05). Logistic regression analysis showed that IL-10 (P <0.05), neutrophil CD64 (P <0.05) and pathological type (P <0.05) were independent risk factors of chronic renal insufficiency in patients. Conclusion Serum levels of IL-10 and neutrophil CD64 are closely related to the effects of hormonal therapy and nephrotic syndrome hormone therapy in patients with nephrotic syndrome.