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目的探讨新型正性肌力活性物PHR0007(三唑并二氢喹啉衍生物)对大鼠动脉血压和心电图的影响和作用机制。方法经股动脉插管连接压力换能器和用针状电极连接标准肢体导联,利用BL-420S生物机能实验系统观察给药前和静脉单用PHR0007(0.1、0.3、1.0μg.kg-1)或米力农(3.8μg.kg-1),以及合用PHR0007(0.1μg.kg-1)和米力农(3.8μg.kg-1)后1 h之内的股动脉血压和肢体标准Ⅱ导联心电图变化。结果与给药前比较,注射PHR0007后0.10~0.75 h内收缩压显著提高(P<0.05)。注射米力农后0.10~0.25 h内收缩压也明显增高(P<0.05)。合用米力农和PHR0007后0.10~0.75 h内收缩压虽然升高(P<0.05),但较单用PHR0007或米力农无明显差异(P>0.05)。0.1μg.kg-1PHR0007使心率减慢(P<0.05)。不同浓度的PHR0007使QT间期延长(P<0.05),且在低剂量更加明显。各种处理因素对舒张压和PR间期无显著性影响。结论类似米力农,PHR0007对大鼠具有强心和扩血管作用。
Objective To investigate the effect and mechanism of a novel inotropic agent PHR0007 (triazole dihydroquinoline derivatives) on arterial blood pressure and electrocardiogram in rats. Methods The standard limb lead was connected to the pressure transducer through the femoral artery and the needle electrode. BL-420S bio-functional system was used to observe the effect of PHR0007 (0.1, 0.3, 1.0 μg.kg-1 ) Or Milrinone (3.8μg.kg-1), and femoral artery blood pressure and limbs within 1 h after PHR0007 (0.1μg.kg-1) and milrinone (3.8μg.kg-1) Lead ECG changes. Results Compared with those before administration, the systolic pressure was significantly increased within 0.10-0.75 h after injection of PHR0007 (P <0.05). Systolic blood pressure was also significantly increased within 0.10 ~ 0.25 h after injection of milrinone (P <0.05). Systolic blood pressure increased within 0.10-0.75 h after combination of milrinone and PHR0007 (P <0.05), but no significant difference (P> 0.05) compared with single use of PHR0007 or milrinone. 0.1 μg.kg-1 PHR0007 slows heart rate (P <0.05). Different concentrations of PHR0007 prolonged the QT interval (P <0.05) and were more pronounced at low doses. Various treatment factors had no significant effect on diastolic blood pressure and PR interval. Conclusion Similar to Milrinone, PHR0007 has cardiotoxic and vasodilator effects in rats.