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目的 调查我国北方 4市城区 2～ 7岁儿童末梢全血锌原卟啉 (ZPP)水平和铁缺乏症患病率。方法 流行病学调查采用是整群随机抽样方法。血红蛋白 (Hb)用氰化高铁法 ,末梢全血ZPP用荧光法 ,血清铁蛋白(SF)用微粒子酶免法。结果 北方 4市城区 (北京、沈阳、丹东和邢台 ) 53 3 3例 2～ 7岁儿童末梢全血ZPP含量中位数分别为 2 .4 ,2 .2 ,2 .6和 2 .8μg/( g·Hb) ,其 95%上限值分别为 3 .7,3 .9,4 .2 ,4 .4 μg/( g·Hb)。随机抽取ZPP为 3 .4～ 4 .4 μg/( g·Hb)的 1 3 8份静脉血清标本 ,其SF值为 ( 43 .61± 1 7.4 2 ) μg/L。 4市城区总贫血、缺铁性贫血(IDA)和红细胞生成缺铁 (IDE)患病率分别为 3 .92、1 .88和 7.63 %。结论 建议采用 4市的ZPP 95%上限值 ,即北京 <3 .7、沈阳 <3 .9、丹东 <4 .2和邢台 <4 .4 μg/( g·Hb)作为这些城市铁缺乏症的诊断标准。
Objective To investigate the level of peripheral ZPP and the prevalence of iron deficiency in children aged 2 ~ 7 years old in 4 cities of northern China. Methods Epidemiological surveys were conducted using a cluster random sampling method. Hemoglobin (Hb) with high-speed ferrotox method, peripheral whole blood ZPP fluorescence method, serum ferritin (SF) with microparticle enzyme free. Results The median ZPP levels in peripheral blood of 533 children aged 2 to 7 years in the four northern urban districts of Beijing (Beijing, Shenyang, Dandong and Xingtai) were respectively 2.4, 2.2, 2.6 and 2. 8 μg / ( g · Hb) with 95% upper limit values of 3.7, 3.9, 9.4, 4. 4 μg / (g · Hb), respectively. A total of 138 venous serum samples with ZPP of 3.4-4.4 μg / (g · Hb) were randomly selected and their SF values were (43.61 ± 1.142) μg / L. The prevalences of total anemia, iron deficiency anemia (IDA) and iron deficiency (IDE) in 4 urban areas were 3.92, 1.88 and 7.63% respectively. Conclusions It is recommended that the upper ZPP 95% limit for four cities be Beijing <3.7, Shenyang <3.9, Dandong <4.2 and Xingtai <4. 4 μg / (g · Hb) for these urban iron deficiency Diagnostic criteria.