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目的本研究采用神经再生室研究白细胞介素－１（Ｉｎｔｅｒｌｅｕｋｉｎ－１，ＩＬ－１）对周围神经再生功能的影响。方法将５７只ＳＤ大白鼠随机分为 ＩＬ— １、白细胞介素－１ｌ受体拮抗剂（Ｉｎｔｅｒｌｅｕｋｉｎ－１ Ｒｅｃｅｐｔｏｒ Ａｎｔｎｇｏｎｉｓｔ，ＩＬ－ １ｒａ）和等渗盐水 ３组。术后 ３、６周取材作神经电生理检查，术后１６周作大鼠趾展宽度测定。结果ＩＬ－１组再生周围神经功能明显优于ＩＬ－１ｒａ组和等渗盐水组。ＩＬ－１ｒａ组和等渗盐水组间没有明显差异。结论ＩＬ－１具有促进周围神经再生及神经功能恢复的作用。
Objective To study the effect of Interleukin-1 (IL-1) on the peripheral nerve regeneration in a nerve regeneration room. Methods 57 SD rats were randomly divided into three groups: IL-1, Interleukin-1 Receptor Antagonist (IL-1ra) and isotonic saline. Neuropsychological tests were performed at 3 and 6 weeks after operation, and the toe width was measured at 16 weeks after operation. Results The peripheral nerve function of IL-1 group was significantly better than IL-1ra group and isotonic saline group. There was no significant difference between the IL-1ra group and the isotonic saline group. Conclusion IL-1 can promote peripheral nerve regeneration and neurological function recovery.