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目的探讨纳洛酮早期干预对重度窒息新生儿脑损伤的影响。方法选取2010年1月-2012年8月于阜阳市第六人民医院进行常规治疗的37例重度窒息新生儿为对照组,以早期纳洛酮干预的37例为观察组,后将两组新生儿三个时期的新生儿行为神经评分(NBNA评分)及治疗前后的血清神经元特异性烯醇化酶(NSE)、S100B蛋白(S100B)、大脑中动脉血流进行比较。结果观察组三个时期的NBNA评分≥35分比例均高于对照组,治疗后3 d、7 d血清NSE、S100B低于对照组,而大脑中动脉收缩期血流速度峰值(Vs)和舒张末期血流速度(Vd)均高于对照组,阻力指数(RI)低于对照组,P均<0.05。结论纳洛酮早期干预对重度窒息新生儿脑损伤程度的近期影响较大。
Objective To investigate the effect of naloxone on early brain injury in neonates with severe asphyxia. Methods Thirty-seven neonates with severe asphyxia treated routinely in the Sixth People’s Hospital of Fuyang City from January 2010 to August 2012 were selected as the control group. 37 cases with early naloxone intervention were selected as the observation group, Neonatal behavioral neurological score (NBNA score) and serum neuron specific enolase (NSE), S100B protein (S100B), middle cerebral artery blood flow before and after treatment were compared. Results The NBNA score ≥35 in the observation group was higher than that in the control group at 3 days. Serum NSE and S100B were lower on the 3rd and 7th day after treatment than those in the control group, while the middle cerebral artery systolic peak velocity (Vs) and diastolic The end-stage blood flow velocity (Vd) was higher than that of the control group, and the resistance index (RI) was lower than that of the control group (all P <0.05). Conclusion Naloxone early intervention has a greater impact on the degree of brain damage in neonates with severe asphyxia.