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目的:采用沉淀聚合法制备黄芩苷分子印迹聚合物并评价其性能。方法:以黄芩苷为模板分子,丙烯酰胺为功能单体,乙二醇二甲基丙烯酸酯为交联剂,偶氮二乙丁腈为引发剂,采用沉淀聚合法制备黄芩苷分子印迹聚合物。用透射电镜和红外光谱分别对聚合物形态和结构进行表征分析。用静态吸附、动态吸附及选择性试验考察聚合物对模板分子吸附性。结果:使用沉淀聚合法得到的分子印迹聚合物具有较好的分散性,形态均匀,粒径分布较好,并且对黄芩苷具有较高的吸附量、较快的吸附速率和高度的选择性。结论:黄芩苷分子印迹聚合物为从黄芩中高效分离活性成分黄芩苷提供新方法。
Objective: To prepare baicalin molecularly imprinted polymer by precipitation polymerization and evaluate its properties. Methods: Baicalin was used as template, acrylamide as functional monomer, ethylene glycol dimethacrylate as crosslinking agent, and azobisisobutyronitrile as initiator to prepare baicalin molecularly imprinted polymer . Transmission electron microscopy and infrared spectroscopy were used to characterize the structure and morphology of the polymer. The adsorption of polymer on template molecule was investigated by static adsorption, dynamic adsorption and selective experiments. Results: The molecularly imprinted polymers obtained by precipitation polymerization showed good dispersibility, uniform morphology, good particle size distribution, high adsorption capacity, fast adsorption rate and high selectivity for baicalin. Conclusion: Baicalin molecularly imprinted polymer provides a new method for the efficient separation of baicalin from Scutellaria baicalensis Georgi.