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目的:观察静脉输注冷沉淀改善有机磷农药中毒患者凝血功能的效果及对肝、肾功能的影响。方法:将急性有机磷农药中毒38例,随机分为观察组和对照组各19例。对照组在治疗有机磷农药中毒的基础上静脉输注新鲜冰冻血浆800 ml/天,连续2天;观察组在对照组治疗的基础上静脉输注冷沉淀10 U/天,连续2天。比较两组凝血功能、心肌酶、肝及肾功能各指标的变化情况。结果:观察组冷沉淀输注后凝血时间(PT)、凝血酶原时间比值(PTR)、国际标准化凝血活酶时间比值(INR)和凝血酶原时间(APTT)显著低于输注前(P<0.05),活动度显著高于输注前(P<0.05);与对照组比较,差异显著(P<0.05)。对照组输注前后PT、PTRI、NR、APTT及活动度差异不显著(P>0.05)。两组输注前后肝、肾功能各指标及心肌酶变化,差异不显著(P>0.05)。结论:静脉输注冷沉淀可显著改善有机磷农药中毒患者的凝血功能。
Objective: To observe the effects of intravenous infusion of cryoprecipitate on coagulation function and liver and kidney function in patients with organophosphorus pesticide poisoning. Methods: 38 cases of acute organophosphorus pesticide poisoning were randomly divided into observation group and control group, 19 cases each. In the control group, fresh frozen plasma of 800 ml / day was intravenously infused intravenously for 2 days on the basis of the treatment of organophosphorus pesticide poisoning. The observation group received 10 U / day intravenous infusion of cryoprecipitate on the basis of the control group for 2 consecutive days. The changes of coagulation, myocardial enzymes, liver and kidney function were compared between the two groups. Results: The coagulation time (PT), prothrombin time (PTR), INR and APTT in the observation group were significantly lower than those before the infusion (P <0.05), and the activity was significantly higher than that before infusion (P <0.05). Compared with the control group, the difference was significant (P <0.05). There was no significant difference in PT, PTRI, NR, APTT and activity before and after infusion in control group (P> 0.05). Before and after infusion of liver and kidney function of each index and myocardial enzyme changes, the difference was not significant (P> 0.05). Conclusion: Intravenous infusion of cryoprecipitate can significantly improve coagulation function in patients with organophosphorus pesticide poisoning.